apalutamide will reduce the extent or impact of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Coadministration of apalutamide, a solid CYP3A4 inducer, with medicines which are CYP3A4 substrates can lead to reduced exposure to these prescription drugs.Modafinil could be routine-forming. By